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KMID : 0363420020160020039
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Journal of Korean Oriental Pediatrics
2002 Volume.16 No. 2 p.39 ~ p.49
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Effect of Kamihyunggyeyungyotang on Interleukin-8 & $TGF-{\beta}1$ in Middle Ear Effusion for Pediatric Recurrent Otitis Media with Effusion
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Kim Hyun-Hee
Park Eun-Jung
Joo Jong-Cheon
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Abstract
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The author measured IL-8 and $TGF-{\beta}1$ levels of 84 ears - 48 ears of them had treated by antibiotics, 36 of them by Kamihyunggyeyungyotang(KHY) - of pediatric recurrent otitis media with effusion using ELISA assay, and compared them. The results were obtained as follows. 1. The level of IL-8 in KHY group was significantly lower than that in antibiotics group(p<0.05). 2. The level of $TGF-{\beta}1$ in KHY group was lower than that in antibiotics group. According to above results, KHY is considered to be used for treating recurrent otitis media with effusion by controlling the production of interleukin-8 and transforming $growthfactor-{\beta}1$.
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KEYWORD
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Middle ear, Otitis media, Hyunggyeyungyotang, Interleukin, Transforming growthfactor
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